Just fine i take one a day and only double up if i feel gout coming on, and it works great

Before he taking go-out plex he would get an attack every couple months and it would last for a week or more

Did not work my husband says these work very well along with a few diet changes at keeping his gout in check sorry to say this not work well for me

I took it during a very bad attack, so bad i was crawling around the house, when using crutches was painful